코로나의 변종

일본과 인도는 폭염 속에서 코로나-19가 확산하는 모양새를 하고 있다. 연구팀은 인체 침투에 관여하는 스파이크 단백질의 변이를 일본의 폭염속 집단 감염에서 확인했다.

이 바이러스는 여름에 확산세가 줄어드는 통상의 특징과 달리 여름의 폭염에도 변이를 거듭하면서 좀처럼 줄어들지 않고 있다.

코로나-19의 이런 특징이 정말 자연적인 바이러스로부터 생긴 현상일까 하는 의심스런 대목이다.

Abstract
The aim of this study is to understand adaptive immunity to SARS-CoV-2 through the analysis of B cell epitope and neutralizing activity in coronavirus disease 2019 (COVID-19) patients. We obtained serum from thirteen COVID-19 patients. Most individuals revealed neutralizing activity against SARS-CoV-2 assessed by a pseudotype virus-neutralizing assay. The antibody production against the spike glycoprotein (S protein) or receptor-binding domain (RBD) of SARS-CoV-2 was elevated, with large individual differences, as assessed by ELISA. In the analysis of the predicted the linear B cell epitopes, two regions (671-690 aa. and 1146-1164 aa.), which were located in S1 and S2 but not in the RBD, were highly reactive with the sera from patients. In the further analysis of the B cell epitope within the S protein by utilizing a B cell epitope array, a hot spot in the N-terminal domain of the S protein but not the RBD was observed in individuals with neutralizing activity. Overall, the analysis of antibody production and B cell epitopes of the S protein from patient serum may provide a novel target for the vaccine development against SARS-CoV-2.

 

https://www.biorxiv.org/content/10.1101/2020.07.22.212761v1?fbclid=IwAR0Hdpl52GphYzABtrGwOC48bBDBHG-USsbHCIbd3UBfcDv5TGRVAisRjSw